测定耐甲氧西林金黄色葡萄球菌临床分离株中各种头孢菌素的接种效应。
Determination of an inoculum effect with various cephalosporins among clinical isolates of methicillin-susceptible Staphylococcus aureus.
机构信息
Division of Infectious Diseases, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Rosario, Provincia de Santa Fe, Argentina.
出版信息
Antimicrob Agents Chemother. 2010 May;54(5):2206-8. doi: 10.1128/AAC.01325-09. Epub 2010 Mar 8.
Abstract
Using 98 clinical methicillin-susceptible Staphylococcus aureus isolates of known beta-lactamase (Bla) type, we found a pronounced inoculum effect for cephalexin (mostly Bla type A and C strains), a mild inoculum effect for cephalothin (especially types B and C), and no inoculum effects for ceftriaxone and cefuroxime. Ceftobiprole showed the lowest MICs at a high inoculum but with a slight increase for Bla-positive versus Bla-negative strains. Since a potential therapeutic effect associated with a cephalosporin inoculum effect has been described, further studies are warranted.
摘要
使用 98 株已知β-内酰胺酶（Bla）类型的临床耐甲氧西林金黄色葡萄球菌分离株，我们发现头孢氨苄（主要是 Bla 类型 A 和 C 株）有明显的接种体效应，头孢噻吩（尤其是类型 B 和 C）有轻度的接种体效应，而头孢曲松和头孢呋辛则没有接种体效应。头孢托罗普在高接种体时表现出最低的 MIC，但 Bla 阳性菌株与 Bla 阴性菌株相比略有增加。由于已经描述了与头孢菌素接种体效应相关的潜在治疗效果，因此需要进一步研究。
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