Narotsky Michael G, Kavlock Robert J
U.S. Environmental Protection Agency, Research Triangle Park, North Carolina.
Curr Protoc Toxicol. 2003 Aug;Chapter 13:Unit13.5. doi: 10.1002/0471140856.tx1305s16.
This unit presents two basic protocols for testing prenatal developmental toxicity in rodents. The standard protocol for assessing prenatal developmental toxicity, often referred to as a Segment II study, describes the methods used for performing cesarean sections and examining cesarean-delivered fetuses for external, skeletal, and visceral alterations. The protocol for the Chernoff/Kavlock assay, a developmental toxicity screen, describes methods for examining parturition, and postnatal growth and viability of prenatally exposed litters.
本单元介绍了两种用于检测啮齿动物产前发育毒性的基本方案。评估产前发育毒性的标准方案，通常称为第二阶段研究，描述了用于进行剖腹产以及检查剖腹产取出的胎儿的外部、骨骼和内脏变化的方法。切尔诺夫/卡夫洛克试验的方案是一种发育毒性筛查，描述了检查产前暴露的一窝幼崽的分娩情况以及产后生长和生存能力的方法。
