Palmer A K
Teratog Carcinog Mutagen. 1987;7(1):95-106. doi: 10.1002/tcm.1770070112.
The underlying principle of the Chernoff/Kavlock assay--namely that prenatal toxicity can be detected by means of simple postnatal endpoints--is strongly supported by experience gained in performing reproductive and developmental toxicity studies to international requirements. Compared with the supposedly more sophisticated procedures of regulatory tests, the simpler endpoints of the assay offer greater speed, economy, consistency and reliability. At the most, there is only a marginal loss of sensitivity in respect of detecting the lowest dosage at which effects may occur. The assay is best used as a concept rather than as a protocol with, "tailored" variations providing effective means of priority selection from a series of chemicals, especially analogue series. The underlying principle is applicable at levels through and beyond formal regulatory testing.
切尔诺夫/卡夫洛克试验的基本原理——即产前毒性可通过简单的产后终点来检测——得到了按照国际要求开展生殖和发育毒性研究所得经验的有力支持。与监管测试中那些据称更为复杂的程序相比，该试验更简单的终点具有更高的速度、经济性、一致性和可靠性。在检测可能产生影响的最低剂量方面，至多只是灵敏度略有损失。该试验最好用作一种理念，而非一种带有“定制”变体的方案，这些变体提供了从一系列化学品（尤其是类似物系列）中进行优先筛选的有效手段。其基本原理适用于正式监管测试及更高层面。
