毛果芸香碱治疗放射性碘治疗患者口干症的疗效：一项初步研究。
Pilocarpine used to treat xerostomia in patients submitted to radioactive iodine therapy: a pilot study.
机构信息
Hospital A. C. Camargo.
出版信息
Braz J Otorhinolaryngol. 2010 Sep-Oct;76(5):659-62. doi: 10.1590/S1808-86942010000500021.
UNLABELLED
Xerostomia complaint is very commonly associated to radioactive iodine therapy. Alternatives to treat this morbidity can offer better quality of life to patients with thyroid cancer submitted to adjuvant iodine therapy.
AIM
to report on the experience with pilocarpine on the treatment of xerostomia in thyroid cancer patients submitted to adjuvant radioactive iodine therapy (RIT).
MATERIALS AND METHODS
The five patients who met the inclusion criteria received 5mg of pilocarpine, 3 tid for one week. Side effects of the drug and subjective response to xerostomia complaints after treatment were evaluated.
DESIGN
it is a prospective, non-randomized study.
RESULTS
Sudoresis was the most frequent side effect of pilocarpine use, followed by fatigue and headache. Two patients reported relief of xerostomia using pilocarpine, but only one patient was able to tolerate the side effects.
CONCLUSIONS
Pilocarpine seems to relieve xerostomia complaints in thyroid cancer patients because it is able to stimulate salivary flow, but the observed side effects made the patients refuse long-term therapy continuation.
目的
报告接受辅助放射性碘治疗（RIT）的甲状腺癌患者中使用毛果芸香碱治疗口干症的经验。
材料和方法
符合纳入标准的 5 名患者接受了 5mg 毛果芸香碱，tid，持续一周。评估药物的副作用和治疗后口干症状的主观反应。
设计
这是一项前瞻性、非随机研究。
结果
毛果芸香碱最常见的副作用是出汗，其次是疲劳和头痛。两名患者报告使用毛果芸香碱后口干症状缓解，但只有一名患者能够耐受副作用。
结论
毛果芸香碱似乎可以缓解甲状腺癌患者的口干症状，因为它能够刺激唾液分泌，但观察到的副作用使患者拒绝长期治疗。
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