Murua V S, Molina V A
Escuela de Psicologia, Facultad de Filosofia y Humanidades, Universidad Nactional de Cordoba, Argentina.
Psychopharmacology (Berl). 1990;102(4):503-6. doi: 10.1007/BF02247132.
Rats exposed to one, three, or seven conditioning sessions defined by an olfactory conditioned stimulus and stress or antidepressant administration as unconditioned stimulus were later tested for their preference for the conditioned olfactory stimulus. A significant reduction of the time spent in the conditioned stimulus was observed in animals exposed to one and three pairings with stress or three pairings with desipramine. A lack of conditioned aversion was observed in animals exposed to seven pairings with either reinforcer. These data could indicate that the adaptative mechanisms elicited by repeated stress or desipramine may be involved in the decrease of conditioned aversion.
将大鼠暴露于由嗅觉条件刺激以及作为非条件刺激的应激或抗抑郁药物给药所定义的1次、3次或7次条件作用训练中，随后测试它们对条件化嗅觉刺激的偏好。在暴露于与应激配对1次和3次或与地昔帕明配对3次的动物中，观察到在条件刺激中花费的时间显著减少。在暴露于与任一强化物配对7次的动物中未观察到条件性厌恶。这些数据可能表明，反复应激或地昔帕明引发的适应性机制可能与条件性厌恶的降低有关。
