铜催化的叔胺与酮或吲哚的交叉脱氢偶联反应。
Copper-catalyzed cross dehydrogenative coupling reactions of tertiary amines with ketones or indoles.
机构信息
Key Laboratory of Mesoscopic Chemistry of MOE, College of Chemistry, and Chemical Engineering, Nanjing University, Nanjing 210093, PR China.
出版信息
Org Lett. 2010 Nov 19;12(22):5214-7. doi: 10.1021/ol102252n. Epub 2010 Oct 21.
A novel cross dehydrogenative coupling (CDC) reaction of N,N-dimethylanilines with methyl ketones by cooperative copper and aminocatalysis has been developed, which leads to the formation of β-arylamino ketones in 42-73% yields. Moreover, the copper-catalyzed alkylation of free (NH) indoles with N,N-dimethylanilines via CDC reaction is also presented, affording alkylated indoles in 52-78% yields.
一种新型的 N,N-二甲基苯胺与甲基酮的交叉脱氢偶联（CDC）反应，通过协同铜和氨基催化作用得以实现，该反应生成了β-芳基氨基酮，产率为 42-73%。此外，通过 CDC 反应，铜催化的游离（NH）吲哚与 N,N-二甲基苯胺的烷基化反应也被提出，得到了烷基化吲哚，产率为 52-78%。
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