Key Laboratory of Mesoscopic Chemistry of MOE, College of Chemistry, and Chemical Engineering, Nanjing University, Nanjing 210093, PR China.
Org Lett. 2010 Nov 19;12(22):5214-7. doi: 10.1021/ol102252n. Epub 2010 Oct 21.
A novel cross dehydrogenative coupling (CDC) reaction of N,N-dimethylanilines with methyl ketones by cooperative copper and aminocatalysis has been developed, which leads to the formation of β-arylamino ketones in 42-73% yields. Moreover, the copper-catalyzed alkylation of free (NH) indoles with N,N-dimethylanilines via CDC reaction is also presented, affording alkylated indoles in 52-78% yields.
一种新型的 N,N-二甲基苯胺与甲基酮的交叉脱氢偶联（CDC）反应，通过协同铜和氨基催化作用得以实现，该反应生成了β-芳基氨基酮，产率为 42-73%。此外，通过 CDC 反应，铜催化的游离（NH）吲哚与 N,N-二甲基苯胺的烷基化反应也被提出，得到了烷基化吲哚，产率为 52-78%。
