Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371.
J Am Chem Soc. 2010 Nov 17;132(45):15852-5. doi: 10.1021/ja106925f. Epub 2010 Oct 21.
The first water-tolerant, ketone-type indium homoenolate was synthesized via the oxidative addition of In/InCl(3) to enones. The reaction proceeds exclusively in aqueous media. Both indium and indium(III) chloride are necessary for the smooth conversion of the reaction. Similar results were obtained when InCl or InCl(2) was used in place of In/InCl(3). The synthetic utility of the indium homoenolate was demonstrated through the synthesis of 1,4-dicarbonyl compounds via palladium-catalyzed coupling of indium homoenolate with acid chloride.
通过铟/三氯化铟（In/InCl3）对烯酮的氧化加成反应，首次合成了耐水性、酮型铟叶立德。该反应仅在水相介质中进行。反应顺利转化需要铟和三氯化铟（InCl3）。当用 InCl 或 InCl2 代替 In/InCl3 时，得到了相似的结果。通过钯催化铟叶立德与酰氯的偶联反应合成 1,4-二羰基化合物，证明了铟叶立德的合成实用性。
