Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, China.
Key Laboratory of Green Chemistry and Technology Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610064, China.
Mol Divers. 2019 Nov;23(4):997-1010. doi: 10.1007/s11030-019-09941-8. Epub 2019 Apr 5.
A Rh(I)/Sc(III) co-catalyzed synthesis of highly valuable functionalized 1,4-diketone derivatives in good yields and with an excellent diastereoselectivity. The established method provides a rapid approach to structurally diverse 1,4-diketone scaffold in a very mild and rapid fashion from simple starting materials. Moreover, the protocol could be easily scaled up to gram-scale synthesis. An attempt to develop an asymmetric version of the Rh(I)/guanidine system was also explored, resulting in a moderate enantioselectivity (71% ee).
铑（I）/钪（III）协同催化高附加值功能化 1,4-二酮衍生物的合成，产率高，非对映选择性好。该方法从简单的起始原料出发，以温和、快速的方式提供了一种构建结构多样的 1,4-二酮骨架的快速方法。此外，该方案可以很容易地放大到克级规模的合成。还尝试开发了不对称的铑（I）/胍体系，得到了中等的对映选择性（71%ee）。
