Ramqvist Torbjörn, Du Juan, Lundén Mikaela, Ahrlund-Richter Sofie, Ferreira Joana, Marions Lena, Sparén Pär, Andersson Sören, Dalianis Tina
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Scand J Infect Dis. 2011 Feb;43(2):115-21. doi: 10.3109/00365548.2010.526957. Epub 2010 Oct 21.
Knowledge of the prevalence of different human papillomavirus (HPV) types in young girls is important for the early detection of changes in HPV prevalence, e.g. due to HPV vaccines. The purpose of this study was to obtain information on the prevalence of 24 different genital HPV types in a group of sexually active young women (aged 15-23 y) attending a major youth healthcare centre in Stockholm, before the introduction of public HPV vaccination of young women in the autumn of 2010. A total of 615 women were analyzed for 24 different, mainly high-risk HPV (HR-HPV) types using multiplex polymerase chain reaction and Luminex technology. A high HPV prevalence in this cohort was demonstrated, particularly with regard to HPV16, but also to all included HR-HPV types. Of the 544 successfully analyzed samples from non-vaccinated individuals, 70% were positive for the HPV types assayed for, and 62% were positive for HR-HPV types. Over a third (34.7%) of the women were infected with HPV16, and a high frequency of infections with HR-HPV types 51 (10.7%), 18 (10.1%), 52 (9.9%) and 73 (9.4%) was also observed. At least 9 different non-vaccine HR-HPV types were present with a prevalence of >6% in this selected group of young women.
了解年轻女孩中不同人乳头瘤病毒（HPV）类型的流行情况，对于早期发现HPV流行率的变化（例如由于HPV疫苗导致的变化）非常重要。本研究的目的是在2010年秋季对年轻女性进行公共HPV疫苗接种之前，获取斯德哥尔摩一家主要青少年医疗中心的一组性活跃年轻女性（年龄在15 - 23岁）中24种不同生殖器HPV类型的流行情况信息。使用多重聚合酶链反应和Luminex技术，对总共615名女性进行了24种不同的、主要是高危HPV（HR - HPV）类型的分析。该队列中显示出较高的HPV流行率，特别是HPV16，所有纳入的HR - HPV类型也是如此。在544个来自未接种疫苗个体的成功分析样本中，70%检测的HPV类型呈阳性，62%的HR - HPV类型呈阳性。超过三分之一（34.7%）的女性感染了HPV16，还观察到51型（10.7%）、18型（10.1%）、52型（9.9%）和73型（9.4%）HR - HPV类型的高感染频率。在这组选定的年轻女性中，至少有9种不同的非疫苗HR - HPV类型的流行率>6%。
