Center of Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Warsaw, Poland.
Free Radic Res. 2011 Mar;45(3):253-65. doi: 10.3109/10715762.2010.525233. Epub 2010 Oct 22.
The paper reviews the rapidly expanding pool of information on cellular and molecular mechanisms of autophagy, including autophagy types, macroautophagy induction, formation of autophagosomes and cross-talk between autophagy and apoptosis. Special attention is given to generation of reactive oxygen species (ROS) in various cellular compartments of cells under stress conditions inducing autophagy. The roles of hydrogen peroxide and superoxide in autophagy are analysed based on the recent experimental work. The relation between ROS and life span prolongation is briefly discussed, with the final conclusion that the paradox of dual role of ROS in life and death may be solved to a considerable extent due to research on autophagy.
本文综述了细胞自噬的细胞和分子机制方面迅速扩展的信息库，包括自噬类型、巨自噬的诱导、自噬体的形成以及自噬与细胞凋亡之间的相互作用。特别关注了在诱导自噬的应激条件下，细胞内各细胞器中活性氧（ROS）的产生。基于最近的实验工作，分析了过氧化氢和超氧阴离子在自噬中的作用。简要讨论了 ROS 与寿命延长之间的关系，最后得出结论，由于对自噬的研究，ROS 在生与死中的双重作用的悖论在很大程度上得到了解决。
