Department of Dermatology, St George Hospital, Sydney, NSW, Australia.
Int J Dermatol. 2010 Nov;49(11):1282-5. doi: 10.1111/j.1365-4632.2010.04557.x.
Gentian violet (GV), a mixture of crystal violet and methyl violet, a dye belonging to the di- and triaminophenylmethanes class and has been widely used for its bactericidal and fungicidal properties. To date, there have been no reports of long-term therapeutic use of GV in epidermolysis bullosa (EB).
Two brothers with nonHerlitz junctional epidermolysis bullosa (JEB) aged 12 and 14 tried topical GV to one lower leg with conventional silicone dressings and this was compared with leaving the other leg with silicone dressings alone, over 4 weeks. Wounds were photographed and measured using Visitrak analysis. Pain, ooze, and appearance were assessed using visual analog scales (VAS) scales and Quality of life using Dermatology Life Quality Index and QOLEB (2) tools.
The side treated with dressings and GV reduced to 14.9 cm(2) (-20.74%) and to 9.5 cm(2) (-56.62%) for dressings alone in the older brother (EB-012) and to 4.2 cm(2) (+20%) and 12.5 cm(2) (-7%) for the younger brother (EB-011) in ulcer size, respectively. Both patients did complain of stinging on the sites treated within a few days. QOL measures and VAS scores did not show any significant change.
GV may be considered to be a therapeutic option for ulcers in nH-JEB patients and potentially other EB subtypes. A formal randomized controlled trial and long-term safety study of GV in EB is recommended.
龙胆紫（GV），一种由结晶紫和甲基紫混合而成的混合物，是一种属于二氨基和三氨基甲苯甲烷类的染料，具有杀菌和抑菌作用。迄今为止，尚未有关于龙胆紫长期治疗表皮松解性水疱病（EB）的报道。
两名 12 岁和 14 岁的非赫利茨交界性表皮松解性水疱病（JEB）兄弟尝试在一条小腿上局部使用龙胆紫，并与单独使用硅酮敷料的另一条腿进行比较，为期 4 周。使用 Visitrak 分析拍摄和测量伤口。使用视觉模拟量表（VAS）量表评估疼痛、渗出物和外观，并使用皮肤病生活质量指数和 QOLEB（2）工具评估生活质量。
在年龄较大的哥哥（EB-012）中，用敷料和 GV 治疗的一侧减少到 14.9 cm²（-20.74%），而单独用敷料治疗的一侧减少到 9.5 cm²（-56.62%），而在弟弟（EB-011）中，溃疡面积分别减少到 4.2 cm²（+20%）和 12.5 cm²（-7%）。两名患者都在几天内抱怨治疗部位刺痛。QOL 测量和 VAS 评分没有显示出任何显著变化。
GV 可被视为治疗 nH-JEB 患者溃疡的一种治疗选择，并且可能对其他 EB 亚型也有效。建议对 GV 在 EB 中的应用进行正式的随机对照试验和长期安全性研究。
