Blanes M, Belinchón I, Merino E, Portilla J, Sánchez-Payá J, Betlloch I
Hospital Marina Baixa, Villajoyosa, Alicante, España.
Actas Dermosifiliogr. 2010 Oct;101(8):702-9.
The introduction of highly active antiretroviral therapy has produced a substantial change in the natural history of human immunodeficiency virus (HIV) infection. The frequency of opportunistic infections and AIDS-related cancers has fallen, though new health problems have developed. Likewise, there has been a change in the spectrum of skin diseases now observed in these patients.
To analyze the prevalence and characteristics of skin disease in a group of HIV-infected outpatients.
A cross-sectional, observational study was performed. All patients who attended the day care unit of the infectious diseases department over a 6-month period (May-October, 2003) were offered the possibility of complete dermatologic examination. Epidemiologic and clinical variables were recorded in all participants, together with the findings on examination of the skin. A comparative study was performed, grouping the patients according to CD4-lymphocyte count and antiretroviral treatment.
The prevalence of dermatoses in the study patients was 98.3%. The most common conditions were xerosis (114 patients, 37.6%), seborrheic dermatitis (94 patients, 31%), distal subungual onychomycosis (80 patients, 26.4%), and viral warts (65 patients, 21.4%). Grouped by etiology, infectious diseases were the most common (68.6%), followed by inflammatory diseases (47.5%).
Mucocutaneous lesions continue to be very common in HIV-infected patients, although there has been a qualitative change in the conditions that these patients present.
高效抗逆转录病毒疗法的引入使人类免疫缺陷病毒(HIV)感染的自然史发生了重大变化。机会性感染和艾滋病相关癌症的发生率有所下降,不过也出现了新的健康问题。同样,这些患者中目前观察到的皮肤病谱也发生了变化。
分析一组HIV感染门诊患者皮肤病的患病率及特征。
进行了一项横断面观察性研究。在6个月期间(2003年5月至10月)到传染病科日间护理病房就诊的所有患者都有机会接受全面的皮肤科检查。记录了所有参与者的流行病学和临床变量以及皮肤检查结果。根据CD4淋巴细胞计数和抗逆转录病毒治疗情况对患者进行分组,进行了一项对比研究。
研究患者中皮肤病的患病率为98.3%。最常见的病症为皮肤干燥(114例患者,37.6%)、脂溢性皮炎(94例患者,31%)、远端甲下甲癣(80例患者,26.4%)和病毒疣(65例患者,21.4%)。按病因分组,感染性疾病最为常见(68.6%),其次是炎症性疾病(47.5%)。
皮肤黏膜病变在HIV感染患者中仍然非常常见,尽管这些患者所患病症已有质的变化。