National Center for Preclinical Reproductive and Genetic Toxicology, National Institute for Research in Reproductive Health (ICMR), Mumbai, Maharashtra, India.
Reprod Toxicol. 2011 Apr;31(3):359-62. doi: 10.1016/j.reprotox.2010.10.008. Epub 2010 Oct 20.
Endocrine disruptors (ED) induce both functional and behavioral reproductive abnormalities. Bisphenol A (BPA) is a known ED that leaches from polycarbonate plastics, as such human exposure is common. Maternal BPA exposure has been shown to have negative effects on the fertility of male offspring. Pregnant rats exposed perinatally to environmentally relevant doses of BPA gave birth to offspring with significantly impaired spermatogenesis and fertility. Perinatal exposure had deleterious effects on the male germ line which manifested as impairments in the fertility of F(1) male offspring and subsequent F(2) and F(3) generations. This overview is an attempt to summarize the currently available data in the literature with regards to perinatal BPA exposure and male fertility.
内分泌干扰物（ED）可引起功能性和行为性生殖异常。双酚 A（BPA）是一种已知的内分泌干扰物，会从聚碳酸酯塑料中渗出，因此人类接触较为常见。母体 BPA 暴露已被证明对雄性后代的生育能力有负面影响。在围产期暴露于环境相关剂量的 BPA 会导致雄性后代的精子发生和生育能力显著受损。围产期暴露对内源性生殖细胞有有害影响，表现为 F(1)雄性后代的生育能力受损，以及随后的 F(2)和 F(3)代。本文综述试图总结目前文献中关于围产期 BPA 暴露与雄性生育力的相关数据。
