Institute of Medical Molecular Biotechnology, Faculty of Medicine, Universiti Teknologi MARA (UiTM), Cawangan Selangor, Kampus Sungai Buloh, Jalan Hospital, Sungai Buloh 47000, Selangor, Malaysia.
Department of Paediatrics, Faculty of Medicine, Universiti Teknologi MARA (UiTM), Cawangan Selangor, Kampus Sungai Buloh, Jalan Hospital, Sungai Buloh 47000, Selangor, Malaysia.
Nutrients. 2022 Jul 5;14(13):2766. doi: 10.3390/nu14132766.
Metabolic syndrome (MS) is a multifactorial disease entity and is not fully understood. Growing evidence suggests that early exposure to bisphenol A (BPA) is a significant risk factor for the development of metabolic diseases. BPA is a monomer used in the manufacturing of polycarbonate plastics, thermal receipt paper, and epoxy resins. Owing to its widespread use, BPA has been detected in human fluids and tissues, including blood, placental breast milk, and follicular fluid. In the present review, we aimed to review the impact of prenatal exposure to different doses of BPA on metabolic parameters as determined by in vivo and epidemiological studies. The PubMed, Scopus, and Web of Science electronic databases were searched to identify articles published during a period of 15 years from 2006 to 2021, and 29 studies met the criteria. Most studies demonstrated that prenatal exposure to low BPA concentrations correlated with alterations in metabolic parameters in childhood and an increased risk of metabolic diseases, such as obesity and type 2 diabetes mellitus (T2DM), in adulthood. Therefore, prenatal exposure to low doses of BPA may be associated with an increased risk of obesity and T2DM in a sex-specific manner.
代谢综合征（MS）是一种多因素疾病实体，目前尚未完全了解。越来越多的证据表明，早期接触双酚 A（BPA）是代谢性疾病发展的一个重要危险因素。BPA 是一种用于制造聚碳酸酯塑料、热敏收据纸和环氧树脂的单体。由于其广泛的用途，BPA 已在人类体液和组织中被检测到，包括血液、胎盘、母乳和卵泡液。在本综述中，我们旨在回顾体内和流行病学研究确定的产前暴露于不同剂量 BPA 对代谢参数的影响。检索了 PubMed、Scopus 和 Web of Science 电子数据库，以确定 2006 年至 2021 年 15 年间发表的文章，共有 29 项研究符合标准。大多数研究表明，产前接触低浓度 BPA 与儿童期代谢参数的改变以及成年后患肥胖症和 2 型糖尿病（T2DM）等代谢性疾病的风险增加相关。因此，产前低剂量 BPA 暴露可能与肥胖症和 T2DM 的风险增加有关，并且具有性别特异性。
