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一名艾滋病患者因隐球菌性脑膜炎并发双侧视神经病变导致突然失明。

Sudden blindness due to bilateral optic neuropathy associated with cryptococcal meningitis in an AIDS patient.

作者信息

Corti Marcelo, Solari Rubén, Cangelosi Diana, Domínguez Cecilia, Yampolsky Claudio, Negroni Ricardo, Arechavala Alicia, Schtirbu Ricardo

机构信息

Division of AIDS, Infectious Diseases F. J. Muñiz Hospital, Buenos Aires, Argentina.

出版信息

Rev Iberoam Micol. 2010 Oct-Dec;27(4):207-9. doi: 10.1016/j.riam.2010.09.002. Epub 2010 Oct 19.

DOI:10.1016/j.riam.2010.09.002
PMID:20965271
Abstract

BACKGROUND

Cryptococcosis is one of the most frequent and severe AIDS defining illnesses.

AIMS

We present a patient with advanced HIV/AIDS disease and a diffuse meningoencephalitis due to Cryptococcus neoformans. The patient developed an acute and bilateral blindness associated with high cerebrospinal fluid pressure and optic neuropathy.

METHODS

Post-mortem anatomopathologic study revealed a high number of Cryptococcus in the central nervous system, including the optic nerves and the optic chiasm.

CONCLUSION

The patient's sudden visual loss appeared to be related to the perineuritic arachnoiditis and the massive invasion of the optic nerves by the fungus.

摘要

背景

隐球菌病是最常见且严重的艾滋病界定疾病之一。

目的

我们报告一名患有晚期人类免疫缺陷病毒/获得性免疫缺陷综合征（HIV/AIDS）疾病且因新型隐球菌导致弥漫性脑膜脑炎的患者。该患者出现了与高脑脊液压力和视神经病变相关的急性双侧失明。

方法

尸检解剖病理学研究显示中枢神经系统，包括视神经和视交叉中有大量隐球菌。

结论

患者的突然视力丧失似乎与神经炎型蛛网膜炎以及真菌对视神经的大量侵袭有关。

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1
Sudden blindness due to bilateral optic neuropathy associated with cryptococcal meningitis in an AIDS patient.一名艾滋病患者因隐球菌性脑膜炎并发双侧视神经病变导致突然失明。
Rev Iberoam Micol. 2010 Oct-Dec;27(4):207-9. doi: 10.1016/j.riam.2010.09.002. Epub 2010 Oct 19.
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Raised intracranial pressure and visual complications in AIDS patients with cryptococcal meningitis.艾滋病合并隐球菌性脑膜炎患者的颅内压升高及视觉并发症
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Bilateral optic nerve cryptococcosis in sudden blindness in patients with acquired immune deficiency syndrome.
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Cryptococcal optic neuropathy in the acquired immune deficiency syndrome.
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Reversible blindness in AIDS-related cryptococcal meningitis.艾滋病相关隐球菌性脑膜炎所致的可逆性失明
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Profile of central nervous system disease in HIV/AIDS patients with special reference to cryptococcal infections.艾滋病病毒/艾滋病患者中枢神经系统疾病概况，特别提及隐球菌感染
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Papilloedema with peripapillary retinal haemorrhages in an acquired immunodeficiency syndrome (AIDS) patient with cryptococcal meningitis.一名患有隐球菌性脑膜炎的获得性免疫缺陷综合征（艾滋病）患者出现视乳头水肿并伴有视乳头周围视网膜出血。
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[Cryptococcosis caused by Cryptococcus neoformans var. Gattii. A case associated with acquired immunodeficiency syndrome (AIDS) in Kinshasa, Zaire].[新型隐球菌格特变种引起的隐球菌病。扎伊尔金沙萨一例与获得性免疫缺陷综合征（艾滋病）相关的病例]
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Clinical manifestations of AIDS with cryptococcal meningitis.艾滋病合并隐球菌性脑膜炎的临床表现。
Chin Med J (Engl). 2001 Aug;114(8):841-3.
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Bilateral multifocal choroiditis and optic neuropathy in a patient with AIDS: a diagnostic dilemma.一名艾滋病患者的双侧多灶性脉络膜炎和视神经病变：诊断难题
AIDS Read. 2007 Dec;17(12):606-8.

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