一名艾滋病患者因隐球菌性脑膜炎并发双侧视神经病变导致突然失明。
Sudden blindness due to bilateral optic neuropathy associated with cryptococcal meningitis in an AIDS patient.
作者信息
Corti Marcelo, Solari Rubén, Cangelosi Diana, Domínguez Cecilia, Yampolsky Claudio, Negroni Ricardo, Arechavala Alicia, Schtirbu Ricardo
机构信息
Division of AIDS, Infectious Diseases F. J. Muñiz Hospital, Buenos Aires, Argentina.
出版信息
Rev Iberoam Micol. 2010 Oct-Dec;27(4):207-9. doi: 10.1016/j.riam.2010.09.002. Epub 2010 Oct 19.
BACKGROUND
Cryptococcosis is one of the most frequent and severe AIDS defining illnesses.
AIMS
We present a patient with advanced HIV/AIDS disease and a diffuse meningoencephalitis due to Cryptococcus neoformans. The patient developed an acute and bilateral blindness associated with high cerebrospinal fluid pressure and optic neuropathy.
METHODS
Post-mortem anatomopathologic study revealed a high number of Cryptococcus in the central nervous system, including the optic nerves and the optic chiasm.
CONCLUSION
The patient's sudden visual loss appeared to be related to the perineuritic arachnoiditis and the massive invasion of the optic nerves by the fungus.
背景
隐球菌病是最常见且严重的艾滋病界定疾病之一。
目的
我们报告一名患有晚期人类免疫缺陷病毒/获得性免疫缺陷综合征（HIV/AIDS）疾病且因新型隐球菌导致弥漫性脑膜脑炎的患者。该患者出现了与高脑脊液压力和视神经病变相关的急性双侧失明。
方法
尸检解剖病理学研究显示中枢神经系统，包括视神经和视交叉中有大量隐球菌。
结论
患者的突然视力丧失似乎与神经炎型蛛网膜炎以及真菌对视神经的大量侵袭有关。
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