Arif Mohammed, Senapati Parijat, Shandilya Jayasha, Kundu Tapas K
Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur (P.O.), Bangalore-560 064, Karnataka, India.
Biochim Biophys Acta. 2010 Oct-Dec;1799(10-12):702-16. doi: 10.1016/j.bbagrm.2010.10.002. Epub 2010 Oct 19.
Lysine acetylation appears to be crucial for diverse biological phenomena, including all the DNA-templated processes, metabolism, cytoskeleton dynamics, cell signaling, and circadian rhythm. A growing number of cellular proteins have now been identified to be acetylated and constitute the complex cellular acetylome. Cross-talk among protein acetylation together with other post-translational modifications fine-tune the cellular functions of different protein machineries. Dysfunction of acetylation process is often associated with several diseases, especially cancer. This review focuses on the recent advances in the role of protein lysine acetylation in diverse cellular functions and its implications in cancer manifestation.
赖氨酸乙酰化对于多种生物学现象似乎至关重要，包括所有以DNA为模板的过程、新陈代谢、细胞骨架动力学、细胞信号传导以及昼夜节律。现在已经鉴定出越来越多的细胞蛋白会发生乙酰化，并构成复杂的细胞乙酰化蛋白质组。蛋白质乙酰化与其他翻译后修饰之间的相互作用精细调节了不同蛋白质机制的细胞功能。乙酰化过程功能失调通常与多种疾病相关，尤其是癌症。本综述重点关注蛋白质赖氨酸乙酰化在多种细胞功能中的作用的最新进展及其在癌症表现中的意义。
