The Key Laboratory of Integrated Crop Pest Management of Shandong Province, College of Agronomy and Plant Protection, Qingdao Agricultural University, Qingdao 266109, China.
College of Life Sciences, Qingdao Agricultural University, Qingdao 266109, China.
Sci Rep. 2016 Jul 14;6:29897. doi: 10.1038/srep29897.
Lysine acetylation is a dynamic and highly conserved post-translational modification that plays an important regulatory role in almost every aspects of cell metabolism in both eukaryotes and prokaryotes. Phytophthora sojae is one of the most important plant pathogens due to its huge economic impact. However, to date, little is known about the functions of lysine acetylation in this Phytopthora. Here, we conducted a lysine acetylome in P. sojae. Overall, 2197 lysine acetylation sites in 1150 proteins were identified. The modified proteins are involved in diverse biological processes and are localized to multiple cellular compartments. Importantly, 7 proteins involved in the pathogenicity or the secretion pathway of P. sojae were found to be acetylated. These data provide the first comprehensive view of the acetylome of P. sojae and serve as an important resource for functional analysis of lysine acetylation in plant pathogens.
赖氨酸乙酰化是一种动态且高度保守的翻译后修饰，在真核生物和原核生物的细胞代谢的几乎所有方面都发挥着重要的调节作用。大豆疫霉是最重要的植物病原体之一，因为它具有巨大的经济影响。然而，迄今为止，人们对这种疫霉中的赖氨酸乙酰化功能知之甚少。在这里，我们对大豆疫霉进行了赖氨酸乙酰基组学研究。总的来说，在 1150 种蛋白质中鉴定出了 2197 个赖氨酸乙酰化位点。这些修饰蛋白参与多种生物过程，并定位于多个细胞区室。重要的是，发现 7 种与大豆疫霉的致病性或分泌途径有关的蛋白质被乙酰化。这些数据提供了大豆疫霉乙酰基组的第一个全面视图，并为植物病原体中赖氨酸乙酰化的功能分析提供了重要资源。
