Jackson State University, Jackson Heart Study, Jackson, Mississippi, USA.
Obesity (Silver Spring). 2011 May;19(5):1054-61. doi: 10.1038/oby.2010.240. Epub 2010 Oct 21.
Leptin, a 16-kDa protein, has proinflammatory properties and has been linked to respiratory physiological responses in majority white populations. Little is known, however, about the relationship of leptin with lung function in nonwhites. Cross-sectional associations of circulating serum leptin concentrations with forced expiratory volume in 1 s (FEV(1)), FEV in 6 s (FEV(6)), and vital capacity (FVC), assessed by spirometry, were examined in 4,679 African-American men and women participants (54.3 ± 12.4 years; 62.7% women) in the Jackson Heart Study (JHS). The independent association of leptin was examined in relation to FEV(1), FEV(6), and FVC% predicted after adjustment for age, education, smoking status, pack-years of cigarette smoking, respiratory medication use, and menopausal status in women; additional adjustment included total body weight, waist circumference, and BMI. Serum leptin was inversely related to FEV(1), FEV(6), and FVC% predicted values in men. A dose-response relationship was observed with men in the highest leptin quartile having a significantly lower lung function compared to men in the lower leptin quartile. BMI significantly modified this relationship in women: leptin was most consistently associated with lung function in obese women, less consistent in overweight women, and absent in normal-weight women. Serum leptin concentration was strongly, inversely, and independently associated with lung function in African Americans, especially African-American men and obese women.
瘦素是一种 16kDa 的蛋白，具有促炎特性，与大多数白种人群的呼吸生理反应有关。然而，关于瘦素与非白种人肺功能的关系，人们知之甚少。通过对 4679 名非裔美国男性和女性参与者（54.3±12.4 岁；62.7%为女性）进行的横断面研究，评估了循环血清瘦素浓度与用力呼气量 1 秒（FEV1）、6 秒用力呼气量（FEV6）和肺活量（FVC）之间的关系，这些参与者均来自于杰克逊心脏研究（JHS）。在调整年龄、教育程度、吸烟状况、吸烟包年数、呼吸系统药物使用和女性绝经状态后，进一步对瘦素与 FEV1、FEV6 和 FVC%预计值的独立相关性进行了研究；在进一步的调整中，还纳入了总体重、腰围和 BMI。血清瘦素与男性的 FEV1、FEV6 和 FVC%预计值呈负相关。在男性中观察到了剂量反应关系，即处于最高瘦素四分位的男性与处于较低瘦素四分位的男性相比，肺功能显著降低。BMI 显著改变了这种关系：在肥胖女性中，瘦素与肺功能的关系最一致，超重女性中瘦素与肺功能的关系较不一致，而正常体重女性中瘦素与肺功能的关系不存在。血清瘦素浓度与非裔美国人的肺功能呈强烈、负相关和独立相关，尤其是非裔美国男性和肥胖女性。
