Palermo University Hospital, Department of Internal Medicine, Cardiovascular Diseases and Nephro-urological Diseases, Palermo, Italy.
Obesity (Silver Spring). 2011 Apr;19(4):875-81. doi: 10.1038/oby.2010.252. Epub 2010 Oct 21.
In addition to well-known electrocardiographic measurements, as QT, QT dispersion, and QT apex dispersion, new parameters such as Tpeak-Tend, Tpeak-Tend dispersion, and Tpeak-Tend/QT ratio have been recently introduced as indexes of increased arrhythmic risk. The aim of the present study was to test, in overweight and obese subjects not affected by conditions of comorbidity, the aforementioned markers of ventricular repolarization. We studied 60 athletic subjects with normal body weight (21 females and 39 males, BMI between 19 and 24, mean BMI 22.0 ± 2.0 kg/m(2), aged 14-64 years, mean age 32 ± 13.59) and 60 sedentary and overweight/obese subjects (34 overweight and 26 obese, 22 females, and 38 males, BMI between 26 and 55, mean BMI 30.7 ± 5.7 kg/m(2), aged 14-64, mean age 38 ± 14.49). Each subject underwent anthropometric measurements and a 12-lead electrocardiogram, from which the following different parameters were calculated: QT, corrected QT, QT dispersion, QT apex dispersion, Tpeak-Tend, Tpeak-Tend dispersion and Tpeak-Tend/QT ratio were calculated. The aforementioned repolarization markers resulted, respectively: 340.2 ± 25.1, 373.8 ± 25.9, 29 ± 16.2, 23.5 ± 14.6, 87.3 ± 12.8, 26.5 ± 16.8, and 0.22 ± 0.03 ms in control subjects and 362.5 ± 28.5, 397.4 ± 35.4, 34.5 ± 16.8, 30.7 ± 16.3, 90.5 ± 15.2, 27 ± 17.1, and 0.22 ± 0.04 ms in overweight/obese subjects. Neither uncomplicated obesity nor overweight were associated with a statistically significant difference in QT dispersion, QT apex dispersion, Tpeak-Tend, Tpeak-Tend dispersion, and Tpeak-Tend/QT ratio; QT and corrected QT were the only parameters that showed statistically significant variations between normal weight and overweight/obese subjects.
除了众所周知的心电图测量指标，如 QT、QT 离散度和 QT 尖端离散度外，新的参数如 Tpeak-Tend、Tpeak-Tend 离散度和 Tpeak-Tend/QT 比值已被引入作为心律失常风险增加的指标。本研究的目的是在不受合并症影响的超重和肥胖受试者中测试上述心室复极标志物。我们研究了 60 名体重正常的运动员（21 名女性和 39 名男性，BMI 在 19 至 24 之间，平均 BMI 为 22.0 ± 2.0kg/m2，年龄在 14 至 64 岁之间，平均年龄为 32 ± 13.59 岁）和 60 名久坐和超重/肥胖受试者（34 名超重和 26 名肥胖，22 名女性和 38 名男性，BMI 在 26 至 55 之间，平均 BMI 为 30.7 ± 5.7kg/m2，年龄在 14 至 64 岁之间，平均年龄为 38 ± 14.49 岁）。每位受试者均进行了人体测量和 12 导联心电图检查，从中计算出以下不同参数：QT、校正 QT、QT 离散度、QT 尖端离散度、Tpeak-Tend、Tpeak-Tend 离散度和 Tpeak-Tend/QT 比值。上述复极标志物在对照组中的结果分别为：340.2 ± 25.1、373.8 ± 25.9、29 ± 16.2、23.5 ± 14.6、87.3 ± 12.8、26.5 ± 16.8 和 0.22 ± 0.03ms，在超重/肥胖组中的结果分别为：362.5 ± 28.5、397.4 ± 35.4、34.5 ± 16.8、30.7 ± 16.3、90.5 ± 15.2、27 ± 17.1 和 0.22 ± 0.04ms。单纯性肥胖或超重均与 QT 离散度、QT 尖端离散度、Tpeak-Tend、Tpeak-Tend 离散度和 Tpeak-Tend/QT 比值无统计学差异；QT 和校正 QT 是体重正常和超重/肥胖受试者之间唯一具有统计学差异的参数。
