Vaupel P, Kallinowski F, Okunieff P
Dept. Radiation Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston 02114.
Adv Exp Med Biol. 1990;277:895-905. doi: 10.1007/978-1-4684-8181-5_103.
The objective of this article was to summarize current knowledge of blood flow and oxygen supply to human tumors, parameters which go hand in hand, and in turn critically determine the cellular metabolic microenvironment of human malignancies. A compilation of available data on blood flow, oxygen supply, and tissue oxygen distribution in human tumors is presented. Though data on human tumors in situ are scarce and there may be significant errors associated with the techniques used for measurements, experimental evidence is provided for the existence of a compromised and anisotropic blood supply to many tumors. Comparable to rodent tumors, O2-depleted areas develop in human malignancies which coincide with nutrient and energy deprivation, and with a hostile metabolic microenvironment. Significant variations in these relevant parameters have to be expected between different locations within the same tumor, at the same location at different times, and between individual tumors of the same grading and staging.
本文的目的是总结目前关于人体肿瘤血流和氧气供应的知识，这两个参数密切相关，进而决定性地决定了人类恶性肿瘤的细胞代谢微环境。本文呈现了关于人体肿瘤血流、氧气供应和组织氧分布的现有数据汇编。尽管关于原位人体肿瘤的数据稀缺，且用于测量的技术可能存在重大误差，但仍有实验证据表明许多肿瘤存在血液供应受损和各向异性的情况。与啮齿动物肿瘤类似，人体恶性肿瘤中会出现缺氧区域，这些区域与营养和能量剥夺以及恶劣的代谢微环境相吻合。在同一肿瘤的不同位置、不同时间的同一位置以及相同分级和分期的个体肿瘤之间，这些相关参数预计会有显著差异。
