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本文引用的文献

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The use of i.v. IG therapy in dermatology.
Dermatol Ther. 2007 Jul-Aug;20(4):288-305. doi: 10.1111/j.1529-8019.2007.00142.x.
2
Effects of treatments on the mortality of Stevens-Johnson syndrome and toxic epidermal necrolysis: A retrospective study on patients included in the prospective EuroSCAR Study.治疗对史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症死亡率的影响：一项针对纳入前瞻性欧洲严重皮肤不良反应研究（EuroSCAR Study）患者的回顾性研究。
J Am Acad Dermatol. 2008 Jan;58(1):33-40. doi: 10.1016/j.jaad.2007.08.039. Epub 2007 Oct 4.
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Practical guidelines for the management of toxic epidermal necrolysis and Stevens-Johnson syndrome.中毒性表皮坏死松解症和史蒂文斯-约翰逊综合征管理实用指南。
Int J Dermatol. 2007 Oct;46(10):1092-4. doi: 10.1111/j.1365-4632.2007.03277.x.
4
Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS): experience with high-dose intravenous immunoglobulins and topical conservative approach. A retrospective analysis.中毒性表皮坏死松解症（TEN）和史蒂文斯-约翰逊综合征（SJS）：大剂量静脉注射免疫球蛋白及局部保守治疗方法的经验。一项回顾性分析。
Burns. 2007 Jun;33(4):452-9. doi: 10.1016/j.burns.2006.08.014. Epub 2007 May 1.
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Efficacy of various intravenous immunoglobulin therapy protocols in autoimmune and chronic inflammatory disorders.各种静脉注射免疫球蛋白治疗方案在自身免疫性和慢性炎症性疾病中的疗效。
Ann Pharmacother. 2007 May;41(5):812-23. doi: 10.1345/aph.1K037. Epub 2007 Apr 17.
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Toxic epidermal necrolysis.中毒性表皮坏死松解症
J Am Acad Dermatol. 2007 Feb;56(2):181-200. doi: 10.1016/j.jaad.2006.04.048.
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Toxic epidermal necrolysis and intravenous immunoglobulin: a review.
Semin Cutan Med Surg. 2006 Jun;25(2):91-3. doi: 10.1016/j.sder.2006.04.004.
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Toxic epidermal necrolysis: analysis of clinical course and SCORTEN-based comparison of mortality rate and treatment modalities in Korean patients.中毒性表皮坏死松解症：韩国患者临床病程分析及基于SCORTEN的死亡率与治疗方式比较
Acta Derm Venereol. 2005;85(6):497-502. doi: 10.1080/00015550510038232.
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Efficacy of low dose intravenous immunoglobulins in children with toxic epidermal necrolysis: an open uncontrolled study.
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10
Intravenous immunoglobulins and plasmapheresis combined treatment in patients with severe toxic epidermal necrolysis: preliminary report.静脉注射免疫球蛋白和血浆置换联合治疗重症中毒性表皮坏死松解症患者：初步报告
Br J Plast Surg. 2005 Jun;58(4):504-10. doi: 10.1016/j.bjps.2004.12.007.

静脉注射免疫球蛋白治疗史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症的综述。

Review of intravenous immunoglobulin in the treatment of stevens-johnson syndrome and toxic epidermal necrolysis.

作者信息

Momin Saira B

机构信息

Saira B. Momin, DO, is Dermatology Resident at Valley Hospital Medical Center, Touro University College of Osteopathic Medicine, Las Vegas, Nevada.

出版信息

J Clin Aesthet Dermatol. 2009 Feb;2(2):51-8.

PMID:20967183
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2958184/
Abstract

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare and serious cutaneous adverse reactions. There is controversy over the use of intravenous immunoglobulin (IVIG) in the treatment of SJS or TEN. The lack of randomized controlled trials to assess the benefits and risks of IVIG is due to its low prevalence and the high mortality rate associated with these cutaneous adverse reactions, especially in TEN. This article reviews published literature on case series that either supports or refutes the use of IVIG in the treatment of SJS or TEN.

摘要

史蒂文斯-约翰逊综合征（SJS）和中毒性表皮坏死松解症（TEN）是罕见且严重的皮肤不良反应。关于静脉注射免疫球蛋白（IVIG）用于治疗SJS或TEN存在争议。缺乏评估IVIG利弊的随机对照试验是由于其发病率低以及与这些皮肤不良反应相关的高死亡率，尤其是在TEN中。本文回顾了已发表的关于支持或反驳IVIG用于治疗SJS或TEN的病例系列文献。