Roberson Erik D
Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, USA.
Methods Mol Biol. 2011;670:1-9. doi: 10.1007/978-1-60761-744-0_1.
Alzheimer's disease and frontotemporal dementia are two of the most common neurodegenerative dementias. Here, we review the clinical presentation, genetic causes, typical neuropathology, and current treatments for these disorders. We then review molecules involved in their pathogenesis and protocols for working with these species and conclude with a discussion of experimental systems and outcome measures for studying these disorders.
阿尔茨海默病和额颞叶痴呆是两种最常见的神经退行性痴呆。在此，我们综述这些疾病的临床表现、遗传病因、典型神经病理学及当前治疗方法。然后，我们综述其发病机制中涉及的分子以及针对这些物种的研究方案，并以对研究这些疾病的实验系统和结果测量的讨论作为总结。
