Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA,
Neurotherapeutics. 2013 Oct;10(4):709-21. doi: 10.1007/s13311-013-0219-0.
This article will review the recent advances in the understanding of the role of epigenetic modifications and the promise of future epigenetic therapy in neurodegenerative dementias, including Alzheimer's disease and frontotemporal dementia.
本文将回顾近年来人们对表观遗传修饰作用的认识进展,以及未来在神经退行性痴呆(包括阿尔茨海默病和额颞叶痴呆)的表观遗传学治疗方面的前景。