Schoilew C, Velinova M, Itschev K
Zentrales Veterinärmedizinisches Forschungsinstitut, Sofia, Bulgarien.
Arch Exp Veterinarmed. 1990;44(5):649-54.
Electron microscopy was used to watch and monitor free as well as phagosomically incorporated multilamellar vesicles (MLV) which were considered to be signs of rapid recycling of phagosomal membranes. Close relations were found to exist between lysosomes, on the one hand, and MLV in phagosomes, on the other. The same applied to MLV and mitochondria or nuclear membranes. Destruction of MLV was highly differentiated. Hints are given in this paper on the kinetics of such processes. These results are considered to be of some relevance to the suitability of liposomes as carriers of pharmaceutical substances.
电子显微镜用于观察和监测游离的以及吞噬体中包含的多层囊泡（MLV），这些被认为是吞噬体膜快速循环利用的标志。一方面发现溶酶体与另一方面吞噬体中的MLV之间存在密切关系。MLV与线粒体或核膜之间也是如此。MLV的破坏具有高度的差异性。本文给出了此类过程动力学的相关提示。这些结果被认为与脂质体作为药物载体的适用性有一定关联。
