苯乙烯马来酸酐对大鼠的长期毒性研究。

Long-term toxicity studies of styrene maleic anhydride in rats.

作者信息

Sethi N, Srivastava R K, Singh R K, Nath D

机构信息

Division of Toxicology, Central Drug Research Institute, Lucknow, India.

出版信息

Biomed Environ Sci. 1990 Dec;3(4):452-7.

PMID:2096850

Abstract

In male Charles Foster rats, polymer styrene maleic anhydride was injected into the lumen of the vas deferens at dose levels of 1.0, 2.5, and 5.0 mg in each vas deferens of Groups II, III, and IV, respectively, while controls (Group I) received 0.03 ml dimethyl sulfoxide in each vas deferens. The rats were observed for 6 months for toxicity. No change in any of the toxicity parameters in test animals as compared to controls was revealed. Hence, the polymer is safe at the doses used within 6 months of injection.

摘要

在雄性查尔斯·福斯特大鼠中，分别向第二组、第三组和第四组大鼠的每条输精管内注射剂量为1.0毫克、2.5毫克和5.0毫克的聚合物苯乙烯马来酸酐，而对照组（第一组）的每条输精管注射0.03毫升二甲基亚砜。观察大鼠6个月的毒性反应。结果显示，与对照组相比，试验动物的任何毒性参数均无变化。因此，在注射后6个月内，该聚合物在所使用的剂量下是安全的。