血管内注射避孕药苯乙烯马来酸酐在雄性大鼠体内与碳酸氢钠的可逆性。

Reversibility with sodium bicarbonate of styrene maleic anhydride, an intravasal injectable contraceptive, in male rats.

作者信息

Koul V, Srivastav A, Guha S K

机构信息

Centre For Biomedical Engineering, Indian Institute of Technology, New Delhi, India.

出版信息

Contraception. 1998 Oct;58(4):227-31. doi: 10.1016/s0010-7824(98)00103-6.

DOI:10.1016/s0010-7824(98)00103-6

PMID:9866004

Abstract

A copolymer of styrene and maleic anhydride (SMA) was dissolved in dimethyl sulphoxide (DMSO) and injected into the lumen of the vas deferens of rats. The polymer was retained in the lumen for a period of more than 90 days. Sodium bicarbonate (10%), pH 8.9, was used to flush the polymeric material from the vas deferens lumen. The reversibility and patency of the vas deferens was thus obtained. Sodium bicarbonate proved to be an effective alternative to dimethyl sulphoxide for reversal.

摘要

将苯乙烯与马来酸酐的共聚物（SMA）溶解于二甲基亚砜（DMSO）中，并注入大鼠输精管腔内。该聚合物在腔内保留了90多天。用pH值为8.9的10%碳酸氢钠溶液冲洗输精管腔内的聚合材料。从而实现了输精管的可逆性和通畅性。事实证明，碳酸氢钠是一种有效的替代二甲基亚砜用于输精管复通的物质。