Chronic toxicity of styrene maleic anhydride, a male contraceptive, in rhesus monkeys (Macaca mulatta).
作者信息
Sethi N, Srivastava R K, Singh R K, Bhatia G S, Sinha N
机构信息
Division of Toxicology, Central Drug Research Institute, Lucknow, India.
出版信息
Contraception. 1990 Sep;42(3):337-47. doi: 10.1016/0010-7824(90)90021-m.
PMID:2289393
Abstract
A newly developed male contraceptive, styrene maleic anhydride (SMA), was injected in the vas deferens of male rhesus monkeys for safety evaluation at the dose of 100 mg (contraceptive dose, CD), 250 mg (CD x 2.5) and 500 mg (CD x 5.0), and the monkeys were kept under observation for one year. The observed behavioural, haematological, biochemical and histopathological parameters in treated monkeys were comparable to controls. The results suggest the polymer SMA to be safe up to 5 times CD in monkeys.
摘要
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