Li Qiang, Jiao Bin, Long Heather Ann
Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Photomed Laser Surg. 2011 Feb;29(2):127-30. doi: 10.1089/pho.2009.2704. Epub 2010 Oct 22.
The aim of this study was to test the effectiveness of photodynamic therapy (PDT) in treating pseudoepitheliomatous hyperplasia (PEH) after skin wounding.
PEH is a difficult-to-treat extreme-degree acanthosis characterized by proliferation of the epithelium. Topical PDT offers an effective and non-invasive treatment for intraepithelial neoplasia and inflammatory dermatosis. These disorders and PEH show the same histological features: epidermal hyperplasia. To our knowledge, there have been no clinical trials published about therapeutic responses of PDT for PEH.
After application of 10-30% methyl aminolaevulinate (MAL) emulsion, each lesion was irradiated with 633-nm red light at a total dose of 113-339 J/cm(2). Therapeutic response was assessed by clinical examination at 3 months.
Only 4 of 16 lesions clinically showed a minimal response. No response was observed in 12 of the 16 lesions, either with different cumulative doses or different concentrations of MAL.
PEH after skin wounding responds poorly to the topical MAL-PDT. Besides removal of underlying diseases, surgical excision is still the recommended first option.
本研究旨在测试光动力疗法（PDT）治疗皮肤创伤后假上皮瘤样增生（PEH）的有效性。
PEH是一种难以治疗的极度棘皮症，其特征为上皮细胞增生。局部光动力疗法为上皮内瘤变和炎性皮肤病提供了一种有效且无创的治疗方法。这些疾病与PEH具有相同的组织学特征：表皮增生。据我们所知，尚未有关于光动力疗法治疗PEH的治疗反应的临床试验发表。
涂抹10%-30%的氨基乙酰丙酸甲酯（MAL）乳剂后，每个病灶用633纳米的红光照射，总剂量为113-339 J/cm²。在3个月时通过临床检查评估治疗反应。
16个病灶中只有4个在临床上显示出轻微反应。16个病灶中有12个未观察到反应，无论使用不同的累积剂量还是不同浓度的MAL。
皮肤创伤后的PEH对局部MAL-PDT反应不佳。除了消除潜在疾病外，手术切除仍是推荐的首选方法。
