Schroeter C A, Kaas L, Waterval J J, Bos P M, Neumann H A M
Department of Lasertherapy, Medical Centre Maastricht, Maastricht, The Netherlands.
J Eur Acad Dermatol Venereol. 2007 Oct;21(9):1170-4. doi: 10.1111/j.1468-3083.2007.02081.x.
The aim of this pilot study was an investigation on photodynamic therapy (PDT) whether it is a good alternative for treating periungual and subungual warts of the hands.
Twenty patients (mean age: 30.5 years) with a total of 40 periungual and subungual warts were treated with PDT. A photosensitizer, 20%delta-aminolevulinic acid was applied on the warts. After a mean incubation time of 4.6 h (SD: 1.2), the warts were irradiated with the VersaLight for 5-30 min (15.2 +/- 4.3 min).
After a mean of 4.5 treatments a mean clearance of 100% was achieved in 90% of the patients. One patient (5%) showed a clearance of 50% and another showed no improvement. The subungual or periungual location of the wart had no influence on the number of treatments or end result (P > 0.05). There were two recurrences during the mean follow-up period of 5.9 months (SD: 7.6). Besides mainly pain and hyperpigmentation, most treatments had no side-effects.
PDT can offer a good alternative for treating periungual warts of the hands. Larger studies are indicated.
本初步研究旨在调查光动力疗法（PDT）是否是治疗手部甲周和甲下疣的良好替代方法。
20例患者（平均年龄：30.5岁），共40个甲周和甲下疣接受了光动力疗法治疗。将一种光敏剂，即20%的δ-氨基乙酰丙酸涂抹在疣体上。平均孵育时间为4.6小时（标准差：1.2）后，用VersaLight对疣体进行5至30分钟（15.2±4.3分钟）的照射。
平均经过4.5次治疗后，90%的患者平均清除率达到100%。1例患者（5%）清除率为50%，另1例无改善。疣体的甲下或甲周位置对治疗次数或最终结果无影响（P>0.05）。在平均5.9个月（标准差：7.6）的随访期内有2例复发。除了主要的疼痛和色素沉着外，大多数治疗没有副作用。
光动力疗法可为治疗手部甲周疣提供一种良好的替代方法。需要进行更大规模的研究。
