Department of Microbiology, Immunology, and Molecular Genetics, UCLA, Los Angeles, CA 90095, USA.
Biol Cell. 2012 Mar;104(3):121-38. doi: 10.1111/boc.201100105. Epub 2011 Dec 28.
Nucleocytoplasmic trafficking of many cellular proteins is regulated by nuclear import/export signals as well as post-translational modifications such as covalent conjugation of ubiquitin and small ubiquitin-related modifiers (SUMOs). Ubiquitination and SUMOylation are rapid and reversible ways to modulate the intracellular localisation and function of substrate proteins. These pathways have been co-opted by some viruses, which depend on the host cell machinery to transport their proteins in and out of the nucleus. In this review, we will summarise our current knowledge on the ubiquitin/SUMO-regulated nuclear/subnuclear trafficking of cellular proteins and describe examples of viral exploitation of these pathways.
许多细胞蛋白的核质运输受核输入/输出信号以及翻译后修饰（如泛素和小泛素相关修饰物（SUMO）的共价连接）调节。泛素化和 SUMO 化是调节底物蛋白细胞内定位和功能的快速和可逆方式。这些途径已被一些病毒采用，这些病毒依赖宿主细胞机制将其蛋白输入和输出细胞核。在这篇综述中，我们将总结我们目前对细胞蛋白的泛素/SUMO 调节的核/亚核运输的了解，并描述病毒利用这些途径的例子。
