Section of Endocrinology and Diabetology, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
J Adolesc Health. 2010 Nov;47(5):433-9. doi: 10.1016/j.jadohealth.2010.05.018. Epub 2010 Jul 29.
Whether the secular trend of a decreasing age of puberty has continued over the past 50 years remains controversial. Data that had been classically used to address this issue are reviewed and large epidemiologic studies, which had not previously been included, are now considered to challenge the conclusions of prior debates of this topic. The effect and timing of excessive weight gain are discussed in detail and recent observations about the opposing effects of obesity on the pubertal timing of girls versus boys are considered. The second half of the review examines both the causes and the long-term health consequences of early puberty, touching on the possible effect of stress and endocrine-disrupting chemicals along with the risks of reproductive cancers, metabolic syndrome, and psychosocial consequences during adolescence and beyond.
过去 50 年来，青春期年龄呈下降趋势这一趋势是否持续存在，仍存在争议。人们对经典数据进行了审查，同时还考虑了以前未包含的大型流行病学研究，这些研究对该主题先前争论的结论提出了挑战。本文详细讨论了超重的影响和发生时间，并考虑了肥胖对女孩和男孩青春期时间的相反影响的最新观察结果。本文后半部分既检查了性早熟的原因，也检查了性早熟的长期健康后果，涉及到压力和内分泌干扰化学物质的可能影响，以及生殖系统癌症、代谢综合征以及青春期及以后的心理社会后果的风险。
