取代苯乙酮芳基/环己基砜腙的吡唑衍生物及其抗分枝杆菌活性。
Pyrazole derivatives from azines of substituted phenacyl aryl/cyclohexyl sulfides and their antimycobacterial activity.
机构信息
Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, India.
出版信息
Bioorg Med Chem Lett. 2010 Dec 1;20(23):6920-4. doi: 10.1016/j.bmcl.2010.09.137. Epub 2010 Oct 7.
PMID:20970331
Abstract
Azines derived from substituted phenacyl aryl/cyclohexyl sulfide on treatment with excess phosphorous oxychloride in N,N-dimethylformamide have been found to yield two isomeric pyrazoles in each case. A plausible mechanism has been suggested for the formation of the products. The antimycobacterial activity of the isomeric compounds has been tested against Mycobacterium tuberculosis (MTB).
摘要
用过量的氧氯化磷在 N,N-二甲基甲酰胺中处理取代的苯乙酰芳基/环己基硫化物，发现每种情况下都能生成两种互变异构的吡唑。对于产物的形成提出了一个合理的机制。对两种异构化合物的抗分枝杆菌活性进行了测试，以对抗结核分枝杆菌（MTB）。
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