5-芳基-1-异烟酰基-3-(吡啶-2-基)-4,5-二氢-1H-吡唑衍生物的合成及其抗分枝杆菌活性
Synthesis and antimycobacterial activity of 5-aryl-1-isonicotinoyl-3-(pyridin-2-yl)-4, 5-dihydro-1H-pyrazole derivatives.
作者信息
Mamolo M G, Zampieri D, Falagiani V, Vio L, Banfi E
机构信息
Dipartimnento di Scienze Farmaceutiche, Università di Trieste, Italy.
出版信息
Farmaco. 2001 Aug;56(8):593-9.
PMID:11601645
Abstract
5-Aryl-1-isonicotinoyl-3-(pyridin-2-yl)-4,5-dihydro-1H-pyrazole derivatives were synthesized and tested for their in vitro antimycobacterial activity. The compounds showed an interesting activity against a strain of Mycobacterium tuberculosis and a human strain of M. tuberculosis H4.
摘要
合成了5-芳基-1-异烟酰基-3-(吡啶-2-基)-4,5-二氢-1H-吡唑衍生物，并对其体外抗分枝杆菌活性进行了测试。这些化合物对一株结核分枝杆菌和一株人源结核分枝杆菌H4显示出有趣的活性。
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