Krzysiek R
INSERM U996, Université Paris-Sud 11 and Hôpital Antoine Béclère, Assistance Publique Hôpitaux de Paris, Clamart, France.
Transplant Proc. 2010 Oct;42(8):3331-2. doi: 10.1016/j.transproceed.2010.07.038.
Dendritic cells (DCs) play a crucial role in T cell allorecognition in the context of organ transplantation and allogeneic hematopoietic stem cell transplantation (allo-HSCT). This DC function is believed to be directly involved in allo-HSCT morbidity and mortality. DC functions range from immunoaggressive responses to the promotion of tolerance, reflecting functional plasticity. This unique characteristic offers a rationale to propose generation of tolerogenic DCs as a therapeutic tool for graft-versus-host disease (GVHD). The accumulated preclinical findings support the concept that glucocorticoid-induced leucine zipper (GLIZ) expression redirects mature DC function toward a tolerogenic mode, driving differentiation of antigen-specific regulatory T cells. Taking into account the unique role of DCs within the allo-HSCT context, novel preventive and curative therapeutics for GVHD might be based on the selective induction of GILZ expression in vivo.
在器官移植和异基因造血干细胞移植（allo-HSCT）的背景下，树突状细胞（DCs）在T细胞同种异体识别中起着关键作用。这种DC功能被认为直接参与了allo-HSCT的发病和死亡。DC的功能范围从免疫攻击性反应到促进耐受性，反映了功能可塑性。这一独特特性为提出生成耐受性DC作为移植物抗宿主病（GVHD）的治疗工具提供了理论依据。积累的临床前研究结果支持这样的概念，即糖皮质激素诱导的亮氨酸拉链（GLIZ）表达将成熟DC功能重定向为耐受性模式，驱动抗原特异性调节性T细胞的分化。考虑到DC在allo-HSCT背景下的独特作用，针对GVHD的新型预防和治疗方法可能基于体内选择性诱导GILZ表达。
