Faculty of Chemistry, University of Gdańsk, Sobieskiego 18, 80-952 Gdańsk, Poland.
J Pharm Biomed Anal. 2011 Feb 20;54(3):577-81. doi: 10.1016/j.jpba.2010.09.013. Epub 2010 Sep 25.
The present paper reports on an analytical method for the routine analysis of perfluorinated carboxylic acids (PFCAs). A rapid method for the derivatization, extraction and determination of PFCAs was developed. Technological samples were extracted with ethyl acetate and the anilides obtained were determined by gas chromatography-mass spectrometry (GC-MS) and gas chromatography with flame ionization detector (GC-FID). Residue levels in cell growth incubation media were determined by GC-FID. Confirmation analysis of PFCAs was carried out by GC-MS in selected ion monitoring (SIM) and total ion current (TIC) modes. The compounds were identified on the basis of retention time and comparison of primary and secondary ions. The results showed that this method provided a simple, rapid and sensitive way of analyzing PFCAs in different matrices.
本文报告了一种用于常规分析全氟羧酸（PFCAs）的分析方法。开发了一种快速衍生化、提取和测定 PFCAs 的方法。技术样品用乙酸乙酯提取，得到的酰亚胺用气相色谱-质谱（GC-MS）和带火焰电离检测器的气相色谱（GC-FID）进行测定。细胞生长孵育介质中的残留水平用 GC-FID 测定。通过 GC-MS 在选择离子监测（SIM）和总离子流（TIC）模式下对 PFCAs 进行确证分析。根据保留时间和一级和二级离子的比较对化合物进行鉴定。结果表明，该方法为不同基质中 PFCAs 的分析提供了一种简单、快速和灵敏的方法。
