Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Ann Thorac Surg. 2010 Nov;90(5):1682-7. doi: 10.1016/j.athoracsur.2010.06.081.
This study evaluated the feasibility and efficacy of a newly developed adjustable left ventricular assist device inflow cannula in a short-term calf model.
In this inflow cannula, the angle between the cannula body and the inflow cannula tip can be altered extracorporeally by manipulating 2 externalized cables connected to the cannula. The cannula tip is adjustable in any plane to a maximum of ±15 degrees.
After initial prototyping in 4 calf cadavers, a Cleveland Heart left ventricular assist device was implanted with the adjustable inflow cannula placed in the left ventricular apex and the outlet to the descending aorta. Under hypovolemic conditions, the angle of the cannula tip could be changed to induce varying degrees of ventricular suction and then eliminate it, as evidenced by recorded pump and native left ventricular flows. Epicardial echocardiography and fluoroscopy in the closed-chest condition documented extracorporeal adjustments of the inflow cannula position.
This extracorporeally adjustable inflow cannula was effective in preventing or controlling left ventricular suction.
本研究旨在评估一种新型可调节左心室辅助装置流入管在短期小牛模型中的可行性和疗效。
在这种流入管中，通过操纵连接到流入管的 2 根外部化电缆，可以在体外改变流入管体和流入管尖端之间的角度。尖端可以在任何平面上最多调节±15 度。
在 4 具小牛尸体进行初步原型设计后，将克利夫兰心脏左心室辅助装置植入，将可调式流入管置于左心室心尖和降主动脉出口处。在低血容量条件下，可改变尖端的角度以引起不同程度的心室抽吸，然后消除它，这可以通过记录泵和原生左心室流量来证明。在闭胸条件下的心外膜超声心动图和透视术记录了体外调整流入管位置。
这种体外可调节的流入管可有效预防或控制左心室抽吸。
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