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基于萘酰亚胺的新型有机硒氰酸盐：寻找毒性较低且仍能保持保护效果的硒形式。

Naphthalimide based novel organoselenocyanates: finding less toxic forms of selenium that would retain protective efficacy.

机构信息

Chittaranjan National Cancer Institute, Department of Cancer Chemoprevention, Kolkata, West Bengal, India.

出版信息

Bioorg Med Chem Lett. 2010 Dec 1;20(23):6951-5. doi: 10.1016/j.bmcl.2010.09.127.

DOI:10.1016/j.bmcl.2010.09.127
PMID:20971640
Abstract

A series of naphthalimide based organoselenocyanates were synthesized and screened for their toxicity as well as their ability to modulate several detoxifying/antioxidative enzyme levels at a primary screening dose of 3 mg/kg b.w. in normal Swiss albino mice for 30 days. Compound 4d showed highest activity in elevating the detoxifying/antioxidant enzymes levels.

摘要

一系列基于萘酰亚胺的有机硒氰酸酯被合成，并在正常瑞士白化病小鼠中以 3mg/kgbw 的初步筛选剂量进行 30 天的毒性筛选以及对几种解毒/抗氧化酶水平的调节能力筛选。化合物 4d 在提高解毒/抗氧化酶水平方面表现出最高的活性。

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