Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Yahatanishiku, Iseigaoka 1-1, Fukuoka, Japan.
J Occup Health. 2010;52(6):325-34. doi: 10.1539/joh.r10003. Epub 2010 Oct 20.
It has been difficult to make reliable hazard assessments of manufactured nanomaterials, because the nanomaterials form large agglomerations in both in vitro and in vivo studies.
In the New Energy and Industrial Technology Development Organization (NEDO) Project of Japan, the physicochemical properties of many manufactured nanomaterials are being measured, and in vitro and in vivo studies are being performed to determine which endpoints are correspond to the hazards and risks of nanomaterials. Focusing on titanium dioxide, fullerenes and carbon nanotubes, we introduce findings made in inhalation and intratracheal installation studies overseas, and together with the findings made in the NEDO project, and also assess the hazards presented by manufactured nanomaterials.
A project by NEDO has succeeded in ensuring the stability of dispersion (nanoscale <100 nm) of manufactured nanomaterials, and is developing hazard assessments of manufactured nanomaterials. In these interim reports, the acceptable exposure concentration of titanium dioxide and fullerene was proposed to be 1.2 mg/m(3) and 0.8 mg/m(3) respirable dust in working environment, respectively.
由于在体外和体内研究中，纳米材料会形成较大的团聚体，因此很难对制造的纳米材料进行可靠的危害评估。
在日本新能源与产业技术开发组织（NEDO）的项目中，正在对许多制造的纳米材料的物理化学性质进行测量，并进行体外和体内研究，以确定哪些终点与纳米材料的危害和风险相对应。本文以二氧化钛、富勒烯和碳纳米管为例，介绍了海外吸入和气管内安装研究的结果，并结合 NEDO 项目的研究结果，对制造纳米材料的危害进行了评估。
NEDO 的一个项目成功地确保了制造的纳米材料分散体（纳米级<100nm）的稳定性，并正在开发制造纳米材料的危害评估。在这些中期报告中，提出了工作环境中二氧化钛和富勒烯的可接受暴露浓度分别为 1.2mg/m(3)和 0.8mg/m(3)可吸入粉尘。
