Morimoto Yasuo
Department of Occupational Pneumology, University of Occupational and Environmental Health, Japan.
Nihon Eiseigaku Zasshi. 2012 May;67(3):396-400. doi: 10.1265/jjh.67.396.
We introduced the report on the pulmonary toxicity of manufactured nanomaterials as a national project in Japan conducted by the New Energy and Industrial Technology Development Organization (NEDO project). Well-characterized and well-dispersed industrial nanomaterials were used in this project. Using multiwall carbon nanotubes (MWCNTs), we conducted intratracheal instillation and inhalation studies. At a low dose (0.2 mg/rat) and a high dose (1 mg/rat) of almost individual MWCNTs, transient and persistent inflammatory responses were induced in the lungs following intratracheal instillation. Well-dispersed MWCNTs at a low concentration (0.37 mg/m3) did not induce pulmonary inflammation. Using single-wall carbon nanotubes (SWCNTs), we also conducted both studies. At low (0.2 mg/rat) and high doses (0.4 mg/rat) of well-dispersed SWCNTs, persistent inflammatory responses were induced in the lungs following intratracheal instillation. Well-dispersed MWCNTs at low and high concentrations (0.03 mg/m3 and 0.13 mg/m3, respectively) did not induce pulmonary inflammation. On the basis of these data from mainly inhalation studies, the acceptable exposure concentration of carbon nanotubes is proposed to be 0.03 mg/m3 in Japan.
我们将关于人造纳米材料肺部毒性的报告作为日本新能源和工业技术开发组织开展的一个国家项目（新能源产业技术综合开发机构项目）进行介绍。本项目使用了特性明确且分散良好的工业纳米材料。我们使用多壁碳纳米管（MWCNTs）进行了气管内滴注和吸入研究。在低剂量（0.2毫克/只大鼠）和高剂量（1毫克/只大鼠）的几乎单个的多壁碳纳米管情况下，气管内滴注后肺部会诱导出短暂和持续的炎症反应。低浓度（0.37毫克/立方米）的分散良好的多壁碳纳米管不会诱发肺部炎症。我们还使用单壁碳纳米管（SWCNTs）进行了这两项研究。在低剂量（0.2毫克/只大鼠）和高剂量（0.4毫克/只大鼠）的分散良好的单壁碳纳米管情况下，气管内滴注后肺部会诱导出持续的炎症反应。低浓度和高浓度（分别为0.03毫克/立方米和0.13毫克/立方米）的分散良好的多壁碳纳米管不会诱发肺部炎症。基于这些主要来自吸入研究的数据，在日本，碳纳米管的可接受暴露浓度被提议为0.03毫克/立方米。
