Department of Obstetrics and Gynecology, Bnai-Zion Medical Center, Haifa, Israel.
Endocrine. 2010 Oct;38(2):303-8. doi: 10.1007/s12020-010-9392-7. Epub 2010 Oct 23.
In pre-eclampsia, poor placentation causes both oxidative and endoplasmic reticulum stress of the placenta. The anti-oxidative protein Haptoglobin has three phenotypes: 1-1, 1-2, and 2-2. Haptoglobin 1-1 is a more potent antioxidant. Our objective was to determine whether haptoglobin 1-1 was less common in women with preeclampsia which is a disease with an oxidatives-stress component, compared to the healthy population. Haptoglobin phenotype was compared in 240 healthy and 120 preeclamptic gravida in a case-control study. Statistical analysis was performed using Chi square test. The prevalence of haptoglobin 1-1 was 13% among healthy women and 6% among preeclamptic women (P=0.049). Secondary analysis was also performed. The prevalence of haptoglobin 1-1 is higher in healthy compared to preeclamptic subjects, a finding compatible with a protective role. Haptoglobin 1-1 might have a protective role in preeclampsia. Further work is needed with more Hp 1-1 subjects before we can conclude on the possible use of Haptoglobin phenotype to assess the risk of preeclampsia.
在子痫前期中，胎盘的不良植入会导致氧化应激和内质网应激。抗氧化蛋白结合珠蛋白有三种表型：1-1、1-2 和 2-2。结合珠蛋白 1-1 是一种更有效的抗氧化剂。我们的目的是确定与健康人群相比，在具有氧化应激成分的疾病子痫前期患者中，是否较少出现结合珠蛋白 1-1。在病例对照研究中，比较了 240 名健康孕妇和 120 名子痫前期孕妇的结合珠蛋白表型。使用卡方检验进行统计分析。健康女性中结合珠蛋白 1-1 的患病率为 13%，子痫前期女性为 6%（P=0.049）。还进行了二次分析。与子痫前期患者相比，健康患者中结合珠蛋白 1-1 的患病率更高，这一发现与保护作用一致。结合珠蛋白 1-1 在子痫前期中可能具有保护作用。在我们能够得出关于结合珠蛋白表型用于评估子痫前期风险的可能用途的结论之前，还需要更多的 Hp 1-1 受试者进行进一步的研究。
