Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center For Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao-tong University School of Medicine, 197 Rui-jin Er Road, Shanghai, 200025, People's Republic of China.
Endocrine. 2010 Oct;38(2):276-82. doi: 10.1007/s12020-010-9384-7. Epub 2010 Oct 23.
The expression of X-linked inhibitor of apoptosis (XIAP) and the P2X7 receptor were demonstrated in a variety of tumors. The purpose of the present study was to investigate the associations of XIAP and P2X7 receptor expression with the clinicopathological features of patients with papillary thyroid carcinoma (PTC). In this cross-sectional study, a total of 62 cases were examined, including 43 patients with PTCs and 19 with benign nodular goiters. XIAP and P2X7 receptor expression were examined by immunohistochemical methods on formalin-fixed, paraffin-embedded thyroid tissues. The staining intensity and extent were evaluated and scored using a semi-quantitative method. The immunohistochemical staining score integrating the intensity and extent of XIAP and P2X7 receptors in PTCs was higher than in nodular goiters. XIAP (OR: 5.6, 95% CI: 1.5-21.1, P=0.009) and P2X7 receptor (OR: 6.1, 95% CI: 1.5-24.4, P=0.007) expression were associated with lymph node metastasis in PTCs. In logistic regression analysis, P2X7 receptor expression, tumor size, and capsular infiltration were predictors for lymph node metastasis (P=0.001). Our results suggested that XIAP and P2X7 receptor expression may predict the aggressiveness of PTC.
X 连锁凋亡抑制蛋白（XIAP）和 P2X7 受体的表达在多种肿瘤中得到证实。本研究旨在探讨 XIAP 和 P2X7 受体表达与甲状腺乳头状癌（PTC）患者临床病理特征的关系。在这项横断面研究中，共检查了 62 例病例，包括 43 例 PTC 患者和 19 例良性结节性甲状腺肿患者。采用免疫组织化学方法检测福尔马林固定、石蜡包埋的甲状腺组织中 XIAP 和 P2X7 受体的表达。采用半定量方法评估和评分染色强度和范围。PTC 中 XIAP 和 P2X7 受体的强度和范围整合的免疫组化染色评分高于结节性甲状腺肿。XIAP（OR：5.6，95%CI：1.5-21.1，P=0.009）和 P2X7 受体（OR：6.1，95%CI：1.5-24.4，P=0.007）表达与 PTC 的淋巴结转移有关。在逻辑回归分析中，P2X7 受体表达、肿瘤大小和包膜浸润是淋巴结转移的预测因子（P=0.001）。我们的结果表明，XIAP 和 P2X7 受体的表达可能预测 PTC 的侵袭性。
