Breast Center, St Luke's International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo, 104-8560, Japan.
Breast Cancer. 2011 Jul;18(3):146-51. doi: 10.1007/s12282-010-0223-8. Epub 2010 Oct 23.
Triple-negative breast cancer is characterized as a cancer with a high malignancy potential and a poor prognosis. Therefore, early detection of this subtype of breast cancer is vital. In this paper, we describe the mammography and ultrasound findings of triple-negative breast cancer in a large population and investigate the specific features of this subtype.
From January 2007 to April 2010, mammography and ultrasound findings of 88 patients with triple-negative breast cancer were retrospectively reviewed. In this cohort, 52 patients underwent neoadjuvant chemotherapy. We compared the pathological chemotherapy effects and radiological findings among these patients. Mammograms were reviewed according to the Japanese mammography guideline. Ultrasound findings were classified as masses, low echoic area, distortions, and calcifications. Noted features included shapes, patterns of internal echoes, posterior echoes, vascularity, and elasticity scores.
On mammography, triple-negative breast cancers frequently presented with a mass (62.4%). Masses with microlobulated margins were the most frequent (39.6%), indistinct (32.0%) and circumscribed (20.8%) were commonly observed, but spiculated margins were rare (4.7%). On ultrasound, cancers were more likely to present as a mass (92.5%), and less likely to show attenuating posterior echoes (8.8%). Of the 40 cases obtained via elasticity imaging, 35 (87.5%) lesions were scored as 4 or 5. There were no significant differences in the mammography or ultrasound findings between the chemotherapy effects.
Mammography and ultrasound imaging together revealed that the morphological features of triple-negative breast cancer include a lobulated mass, with less attenuating posterior echoes, some vascularity, and low elasticity.
三阴性乳腺癌的特点是恶性程度高、预后差。因此，早期发现这种乳腺癌亚型至关重要。本文描述了大样本量三阴性乳腺癌的乳腺 X 线摄影和超声表现，并探讨了该亚型的特征。
回顾性分析 2007 年 1 月至 2010 年 4 月 88 例三阴性乳腺癌患者的乳腺 X 线摄影和超声表现。该队列中有 52 例患者接受了新辅助化疗。比较了这些患者的病理化疗效果和影像学表现。乳腺 X 线摄影结果按照日本乳腺 X 线摄影指南进行评估。超声表现分为肿块、低回声区、扭曲和钙化。注意的特征包括形状、内部回声模式、后方回声、血管分布和弹性评分。
在乳腺 X 线摄影中，三阴性乳腺癌常表现为肿块（62.4%）。具有微叶状边缘的肿块最常见（39.6%），边界模糊（32.0%）和边界清楚（20.8%）较为常见，而有毛刺状边缘的较少见（4.7%）。在超声中，癌症更常表现为肿块（92.5%），较少出现衰减的后方回声（8.8%）。在弹性成像的 40 例中，35 例（87.5%）病变评分 4 或 5 分。化疗效果的乳腺 X 线摄影和超声表现无显著差异。
乳腺 X 线摄影和超声成像联合显示，三阴性乳腺癌的形态学特征包括有分叶的肿块，较少出现衰减的后方回声，一些血管分布和低弹性。
