肠杆菌科生物素维生素异构体的生物合成。

Biosynthesis of biotin-vitamers by family Enterobacteriaceae.

作者信息

Ohsugi M, Imanishi Y, Teraoka T, Nishimura K, Nakao S

机构信息

Department of Food Science, Faculty of Home Economics, Mukogawa Women's University, Nishinomiya, Japan.

出版信息

J Nutr Sci Vitaminol (Tokyo). 1990 Oct;36(5):447-56. doi: 10.3177/jnsv.36.447.

DOI:10.3177/jnsv.36.447

PMID:2097319

Abstract

The biosynthesis of biotin-vitamers from various carbon sources by the members of the Enterobacteriaceae as one of the groups of intestinal bacteria was investigated. The biotin-vitamers synthesized in each case included one or more of dethiobiotin (main product), 7-keto-8-aminopelargonic acid, and biotin. True biotin was shown to be synthesized under aerobic conditions but not under anaerobic conditions by each of several strains belonging to one of the genera, Erwinia, Escherichia, Proteus, and Serratia, and using culture media containing one of galactose, peptone, Polypepton, or casamino acid. In addition, a biotin precursor, pimelic acid, was also synthesized by several bacteria utilizing carbon sources such as maltose, mannose, galactose, peptone, or casamino acid.

摘要

作为肠道细菌群体之一的肠杆菌科成员利用各种碳源生物合成生物素维生素类似物的情况进行了研究。在每种情况下合成的生物素维生素类似物包括脱硫生物素（主要产物）、7-酮-8-氨基壬酸和生物素中的一种或多种。属于欧文氏菌属、大肠杆菌属、变形杆菌属和沙雷氏菌属之一的几个菌株，在有氧条件下但不在厌氧条件下，使用含有半乳糖、蛋白胨、聚蛋白胨或酪蛋白氨基酸之一的培养基，均能合成真生物素。此外，几种细菌利用麦芽糖、甘露糖、半乳糖、蛋白胨或酪蛋白氨基酸等碳源也能合成生物素前体庚二酸。