生物素维生素类似物的微生物活性。

Microbiological activity of biotin-vitamers.

作者信息

Ohsugi M, Imanishi Y

出版信息

J Nutr Sci Vitaminol (Tokyo). 1985 Dec;31(6):563-72. doi: 10.3177/jnsv.31.563.

DOI:10.3177/jnsv.31.563

Abstract

The growth requirement or growth-promoting effect of biotin-vitamers on bacteria and yeasts was investigated. Biotin, dethiobiotin and biocytin (N-e-biotinyl-L-lysine) were shown to be required for growth in a number of bacteria and yeasts. The biological activity of dethiobiotin was relatively higher than that of biotin, but was negative for lactic acid bacteria. Biocytin had high activity for Bacillus subtilis (natto), Debaryomyces japonicus and Hansenula capsulata. The biotin activity of 7-keto-8-aminopelargonic and 7,8-diaminopelargonic acids was low or negligible for bacteria but relatively high for yeasts such as the genera of Endomyces, Endomycopsis and Saccharomyces. Pimelic, pelargonic and pelargonylhydroxamic acids had no growth requirement for or growth-promoting effect on any of the bacteria or yeasts tested.

摘要

研究了生物素维生素对细菌和酵母的生长需求或生长促进作用。结果表明，生物素、脱硫生物素和生物胞素（N - ε - 生物素基 - L - 赖氨酸）是许多细菌和酵母生长所必需的。脱硫生物素的生物活性相对高于生物素，但对乳酸菌呈阴性。生物胞素对枯草芽孢杆菌（纳豆）、日本德巴利酵母和荚膜汉逊酵母具有高活性。7 - 酮 - 8 - 氨基壬酸和7,8 - 二氨基壬酸的生物素活性对细菌而言较低或可忽略不计，但对诸如内孢霉属、拟内孢霉属和酿酒酵母属等酵母而言相对较高。庚二酸、壬酸和壬酰异羟肟酸对所测试的任何细菌或酵母均无生长需求或生长促进作用。