米非司酮对妊娠和非妊娠宫颈扩张的影响。

Effect of mifepristone on dilatation of the pregnant and non-pregnant cervix.

作者信息

Gupta J K, Johnson N

机构信息

University Department of Obstetrics and Gynaecology, St James's University Hospital, Leeds, UK.

出版信息

Lancet. 1990 May 26;335(8700):1238-40. doi: 10.1016/0140-6736(90)91303-r.

DOI:10.1016/0140-6736(90)91303-r

PMID:1971320

Abstract

The effect of the progesterone antagonist mifepristone on the cervix was investigated in two randomised double-blind placebo-controlled trials, the first in 30 women undergoing first trimester surgical termination of pregnancy and the second in 30 non-pregnant premenopausal women. 600 mg mifepristone, given orally 48 h before surgery, increased the mean preoperative cervical dilatation in both pregnant and non-pregnant treatment groups and also reduced the force required to dilate the pregnant and non-pregnant cervix.

摘要

在两项随机双盲安慰剂对照试验中，研究了孕激素拮抗剂米非司酮对宫颈的影响。第一项试验有30名接受孕早期人工流产手术的女性参与，第二项试验有30名未怀孕的绝经前女性参与。在手术前48小时口服600毫克米非司酮，在怀孕和未怀孕的治疗组中均增加了术前宫颈平均扩张度，并且还降低了扩张怀孕和未怀孕宫颈所需的力量。