Samuel Sumant, Ismavel Ravichand, Boopalan P R J V C, Matthai Thomas
Department of Orthopaedics, Christian Medical College, Vellore, Tamilnadu, India.
Acta Orthop Belg. 2010 Aug;76(4):543-5.
Local antibiotic delivery with antibiotic loaded acrylic bone cement has been used extensively in the management of chronic osteomyelitis and implant related infections. Though newer drug delivery vehicles are being investigated, it remains the most widely used local antibiotic delivery vehicle in orthopaedic surgery. Self-made antibiotic loaded bone cement beads, which are cheaper and antibiotic specific, have been shown to elute less effectively than commercial antibiotic loaded cement beads. We offer several tips for increasing the elution and effectiveness of antibiotic loaded bone cement in clinical practice.
含抗生素的丙烯酸骨水泥局部抗生素递送已广泛用于慢性骨髓炎和植入物相关感染的治疗。尽管正在研究更新的药物递送载体，但它仍然是骨科手术中使用最广泛的局部抗生素递送载体。自制的含抗生素骨水泥珠，其成本更低且具有抗生素特异性，但已证明其洗脱效果不如市售的含抗生素骨水泥珠。我们提供了一些在临床实践中提高含抗生素骨水泥洗脱率和有效性的技巧。
