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本文引用的文献

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Practical considerations in the making and use of high-dose antibiotic-loaded bone cement.高剂量抗生素骨水泥制备与使用中的实际考量
Acta Orthop Belg. 2010 Aug;76(4):543-5.
2
A simple method for fashioning an antibiotic cement-coated interlocking intramedullary nail.一种制作抗生素骨水泥涂层交锁髓内钉的简易方法。
Am J Orthop (Belle Mead NJ). 2010 Jan;39(1):18-21.
3
Use of antibiotic cement-impregnated intramedullary nail in treatment of infected non-union of long bones.抗生素骨水泥浸润髓内钉在治疗长骨感染性骨不连中的应用。
Indian J Orthop. 2009 Oct;43(4):396-402. doi: 10.4103/0019-5413.55468.
4
Temperature evaluation during PMMA screw augmentation in osteoporotic bone--an in vitro study about the risk of thermal necrosis in human femoral heads.骨质疏松性骨中聚甲基丙烯酸甲酯螺钉强化过程中的温度评估——一项关于人类股骨头热坏死风险的体外研究
J Biomed Mater Res B Appl Biomater. 2009 Aug;90(2):842-8. doi: 10.1002/jbm.b.31353.
5
Antibiotic cement-coated nails for the treatment of infected nonunions and segmental bone defects.抗生素骨水泥涂层髓内钉治疗感染性骨不连和节段性骨缺损
J Bone Joint Surg Am. 2008 Nov;90 Suppl 4:163-74. doi: 10.2106/JBJS.H.00753.
6
Biological and biomechanical effects of vancomycin and meropenem in acrylic bone cement.万古霉素和美罗培南在丙烯酸骨水泥中的生物学和生物力学效应。
J Arthroplasty. 2008 Dec;23(8):1232-8. doi: 10.1016/j.arth.2007.10.010. Epub 2008 Apr 14.
7
Infected nonunion of the long bones.长骨感染性骨不连
J Orthop Trauma. 2007 Aug;21(7):507-11. doi: 10.1097/BOT.0b013e31812e5578.
8
Antibiotic cement-coated interlocking nail for the treatment of infected nonunions and segmental bone defects.抗生素骨水泥涂层交锁髓内钉治疗感染性骨不连和节段性骨缺损
J Orthop Trauma. 2007 Apr;21(4):258-68. doi: 10.1097/BOT.0b013e31803ea9e6.
9
Use of antibiotic cement rod to treat intramedullary infection after nailing: preliminary study in 19 patients.使用抗生素骨水泥棒治疗髓内钉固定术后髓内感染:19例患者的初步研究
Arch Orthop Trauma Surg. 2007 Dec;127(10):945-51. doi: 10.1007/s00402-007-0315-x. Epub 2007 Mar 27.
10
Antibiotic-loaded bone cement for infection prophylaxis in total joint replacement.用于全关节置换术中预防感染的载抗生素骨水泥
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一种制作抗生素浸渍骨水泥棒的简单方法,用于长骨感染性骨不连的髓内植入。

A simple method for fashioning an antibiotic impregnated cemented rod for intramedullary placement in infected non-union of long bones.

作者信息

Bharti Ajay, Saroj Umesh Kumar, Kumar Vineet, Kumar Sanjay, Omar Balram Ji

机构信息

GSVM Medical College, Kanpur, UP, India.

Govt. Medical College, Azamgarh, UP, India.

出版信息

J Clin Orthop Trauma. 2016 Oct-Dec;7(Suppl 2):171-176. doi: 10.1016/j.jcot.2016.08.004. Epub 2016 Aug 31.

DOI:10.1016/j.jcot.2016.08.004
PMID:28053381
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5197058/
Abstract

The intramedullary insertion of antibiotic impregnated PMMA rods, beads or nails are widely used and accepted modality of treatment for chronic osteomyelitis of long bones. But at times it becomes difficult to insert and remove these antibiotic delivery systems owing to narrowed medullary canals. Here we present a technique for preparing PMMA rods with diameter ranging from 6 mm to 3 mm. These rods could easily be placed in narrow intramedullary canal of long bones with chronic osteomyelitis or infected non-union. We have used high viscosity bone cement (Simplex P) along with two antibiotics (cefuroxime and vancomycin) for preparing cement rods. Food grade straw and low profile teflon tube guide wire exchanger used in IM nailing were used as mold. Ilizarov wire, 1 mm K wire and 24 gauge stainless steel wire were used as internal support core material for imparting strength. We used this technique in seven cases and were successful in treating infection of long bones of upper and lower limbs (femur). With average follow up of 7.28 months rate of union in our series was 71% (five cases). Four cases (57%) had no evidence of infection and two cases (29%) had control of infection and in one case (14%) infection was still there but union was achieved.

摘要

抗生素浸渍的聚甲基丙烯酸甲酯(PMMA)棒、珠或钉的髓内植入是治疗长骨慢性骨髓炎广泛应用且被认可的治疗方式。但有时由于髓腔变窄,插入和取出这些抗生素输送系统会变得困难。在此,我们介绍一种制备直径范围为6毫米至3毫米的PMMA棒的技术。这些棒可以很容易地放置在患有慢性骨髓炎或感染性骨不连的长骨狭窄髓腔内。我们使用高粘度骨水泥(Simplex P)以及两种抗生素(头孢呋辛和万古霉素)来制备骨水泥棒。髓内钉固定术中使用的食品级吸管和低调聚四氟乙烯管导丝交换器用作模具。伊里扎洛夫钢丝、1毫米克氏针和24号不锈钢丝用作内部支撑芯材以增强强度。我们将该技术应用于7例患者,成功治疗了上肢和下肢(股骨)长骨感染。平均随访7.28个月,我们系列病例的骨愈合率为71%(5例)。4例(57%)无感染迹象,2例(29%)感染得到控制,1例(14%)仍有感染但实现了骨愈合。