Takeuchi N, Go S, Murase M, Nomura Y, Takase H, Uchida K
Endocrinology. 1986 May;118(5):1787-94. doi: 10.1210/endo-118-5-1787.
Serum triglyceride and very low density lipoprotein (VLDL) concentrations were higher in male spontaneously hypertensive rat than in male control Wistar Kyoto rat, whereas serum cholesterol, phospholipids, and high density lipoprotein (HDL) concentrations were lower. Castration of hypertensive rats induced an increase in serum cholesterol, phospholipids, and HDL, and a decrease in serum triglyceride and VLDL. The cholesterol content of HDL increased, whereas the triglycerides decreased after gonadectomy of hypertensive rats. These changes in serum lipids and lipoproteins could be reversed by the administration of testosterone. Apolipoprotein E contents in VLDL and HDL of hypertensive rats were low when compared with control rats but rose after castration and could be reduced by testosterone administration. Hypertensive rats accumulated triglycerides and cholesterol in the liver, which resulted in an increase of liver weight. Castration reduced the hepatic lipids as well as liver weight. The effects of castration and testosterone treatment on lipids and lipoproteins were more prominent in spontaneously hypertensive rats than in control rats. These results suggest that testosterone reduces VLDL catabolism which is related to changes of apolipoprotein composition, and that hypertensive rats are more sensitive to testosterone than control rats.
雄性自发性高血压大鼠的血清甘油三酯和极低密度脂蛋白（VLDL）浓度高于雄性对照Wistar Kyoto大鼠，而血清胆固醇、磷脂和高密度脂蛋白（HDL）浓度则较低。切除高血压大鼠的睾丸会导致血清胆固醇、磷脂和HDL增加，血清甘油三酯和VLDL减少。高血压大鼠去势后，HDL的胆固醇含量增加，而甘油三酯减少。这些血清脂质和脂蛋白的变化可通过给予睾酮来逆转。与对照大鼠相比，高血压大鼠VLDL和HDL中的载脂蛋白E含量较低，但去势后升高，且给予睾酮后可降低。高血压大鼠肝脏中积累了甘油三酯和胆固醇，导致肝脏重量增加。去势可减轻肝脏脂质以及肝脏重量。去势和睾酮治疗对脂质和脂蛋白的影响在自发性高血压大鼠中比在对照大鼠中更显著。这些结果表明，睾酮降低了与载脂蛋白组成变化相关的VLDL分解代谢，并且高血压大鼠比对照大鼠对睾酮更敏感。
