Sane S Y, Nainaney K H
Department of Pathology, Seth G. S. Medical College, Parel, Bombay, Maharashtra.
J Postgrad Med. 1990 Jan;36(1):16-9.
Histiocytosis-X encompasses a wide clinical spectrum from a benign localised lesion to acute generalised disease with malignant behaviour. We have reviewed material from our 18 retrospective cases comparing histological features with clinical data. Degree of positivity for S-100 protein was studied by immunoperoxidase method. Our results indicate that diagnosis of histiocytosis-X necessitates histological confirmation but grading of histological criteria and S-100 positivity do not allow prediction of severity and extent of the disease.
组织细胞增多症-X涵盖了从良性局限性病变到具有恶性行为的急性全身性疾病的广泛临床谱。我们回顾了来自18例回顾性病例的资料，将组织学特征与临床数据进行了比较。采用免疫过氧化物酶法研究了S-100蛋白的阳性程度。我们的结果表明，组织细胞增多症-X的诊断需要组织学证实，但组织学标准的分级和S-100阳性情况无法预测疾病的严重程度和范围。
