Department of Chemistry, Texas Christian University, Ft Worth, Texas 76129, United States.
Mol Pharm. 2010 Dec 6;7(6):2232-9. doi: 10.1021/mp100227m. Epub 2010 Nov 16.
In this work, nanostructured particles of porous silicon are demonstrated to act as an effective carrier for the sustained delivery of antibacterial agents with an enhanced inhibitory activity. Methods are described for the incorporation of significant amounts of the established antibacterial compound triclosan (Irgasan) into mesoporous silicon of varying porosities. Such materials were characterized by a combination of scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX), X-ray diffraction (XRD), thermal gravimetric analysis (TGA), and antimicrobial assays. Assessment of antibacterial activity was carried out versus the bacterium Staphylococcus aureus as a function of time with concomitant assessment of triclosan release; significant, sustained inhibition of bacterial growth is demonstrated in the triclosan-containing porous Si for time intervals greater than 100 days. Significantly, enhanced dissolution (relative to room temperature equilibrium solubility) of the triclosan was observed for the initial 15 days of drug release, inferring some amorphization or nanostructuring by the porous Si matrix.
在这项工作中，多孔硅的纳米结构颗粒被证明是一种有效的载体，可用于持续输送具有增强抑制活性的抗菌剂。文中介绍了将大量已建立的抗菌化合物三氯生（Irgasan）掺入不同孔隙率的介孔硅中的方法。这些材料通过扫描电子显微镜 (SEM)、能量色散 X 射线分析 (EDX)、X 射线衍射 (XRD)、热重分析 (TGA) 和抗菌分析进行了表征。抗菌活性的评估是针对金黄色葡萄球菌作为时间函数进行的，同时评估了三氯生的释放；在含有三氯生的多孔硅中，细菌生长的抑制作用显著且持续，时间间隔大于 100 天。重要的是，在药物释放的最初 15 天内观察到三氯生的溶解增强（相对于室温平衡溶解度），这表明多孔硅基质发生了某种非晶化或纳米结构化。
